Journal article
Maternal 25-hydroxyvitamin D is inversely correlated with foetal serotonin
P Murthi, M Davies-Tuck, M Lappas, H Singh, J Mockler, R Rahman, R Lim, B Leaw, J Doery, EM Wallace, PR Ebeling
Clinical Endocrinology | WILEY | Published : 2017
DOI: 10.1111/cen.13281
Abstract
Objective: Maternal vitamin D deficiency during pregnancy has been linked to impaired neurocognitive development in childhood. The mechanism by which vitamin D affects childhood neurocognition is unclear but may be via interactions with serotonin, a neurotransmitter involved in foetal brain development. In this study, we aimed to explore associations between maternal and foetal vitamin D concentrations, and foetal serotonin concentrations at term. Study design and measurements: Serum 25-hydroxyvitamin D (25(OH)D, nmol/l) and serotonin (5-HT, nmol/l) concentrations were measured in maternal and umbilical cord blood from mother–infant pairs (n = 64). Association between maternal 25(OH)D, cord ..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
PM and PRE received funding from the Australian Institute of Musculoskeletal Science, Western Health, St. Albans, Victoria 3021, Australia. ML is supported by a Career Development Fellowship from the National Health and Medical Research Council (NHMRC; grant no. 1047025). Monash Health is supported by the Victorian Government's Operational Infrastructure Support Program. The authors would like to thank the women who consented to provide samples to the study. The following are gratefully acknowledged: the clinical Research Midwives Genevieve Christophers, Gabrielle Pell and Rachel Murdoch for sample collection and the Obstetrics and Midwifery staff of the Mercy Hospital for Women and Monash Health for their co-operation.